https://nuheals.com/pain-relief/norco/ For overnight pain relief, Norco can be effective in reducing pain so you can sleep more comfortably. The combination of hydrocodone and acetaminophen works quickly and is often prescribed for short-term use when pain is severe and needs to be controlled for a few hours at a time. However, it’s important to note that taking Norco in the evening may cause drowsiness, which can help with sleep, but it should only be used according to a doctor’s instructions, especially if pain relief is needed overnight.