Lortab 7.5/325 mg is a prescription medication that combines 7.5 mg of hydrocodone, which is an opioid pain reliever, with 325 mg of acetaminophen. It's typically used to manage moderate to moderately severe pain that can't be effectively treated with non-opioid medications alone. Hydrocodone changes the way your brain processes pain, while acetaminophen boosts pain relief and helps lower fever.