Lortab 5/325 mg is a combination of 5 mg of hydrocodone, which is an opioid pain reliever, and 325 mg of acetaminophen. This blend is designed to effectively tackle mild to moderate pain. The hydrocodone works by blocking pain signals in your brain, while acetaminophen enhances pain relief and helps lower fever. This lower-strength option is often given for initial pain management or to patients who may be sensitive to stronger opioids.