Lortab 10/325 mg packs a punch with 10 mg of hydrocodone and 325 mg of acetaminophen, making it one of the more potent options in the Lortab family. It's typically prescribed for managing moderate to severe pain when other treatments just aren't cutting it. Hydrocodone works by targeting pain receptors in the brain, while acetaminophen boosts the pain-relieving effects and helps lower fever. Because of its strength, this medication comes with a greater risk of side effects, including sedation, liver damage.