The key differences between Hydrocodone and Oxycodone, two strong prescription pain relievers. Both of these medications are opioids designed to tackle moderate to severe pain, but they have some important distinctions in their chemical makeup, strength, and possible side effects. Hydrocodone is frequently mixed with acetaminophen or ibuprofen, which makes it a go-to option for relief after surgery. On the other hand, Oxycodone comes in both immediate and extended-release forms, offering flexible choices for managing chronic pain.