Oxycodone begins working within 10-30 minutes, peaks after about one hour. Its effects typically last between four to six hours, depending on individual metabolism, liver function, dosage, and other factors. The drug’s half-life is around three to five hours, meaning you can expect it to clear from your bloodstream in 15-25 hours. Metabolites may be detectable in urine for up to 4 days and in hair for up to 90 days. Factors like age, hydration, and kidney function can influence this timeline.