https://newlifemedix.com/what-is-the-difference-between-oxycontin-and-oxycodone/ Both are narcotic or opioid medications that help to relieve pain and are used to relieve moderate to severe pain. The difference between oxycontin and oxycodone is oxycontin is a time-release version of oxycodone. Oxycontin is a controlled-release medication, and oxycodone is an immediate-release medication.