Are you worried about the drug tests for Tramadol? After using Tramadol for a long time, it is not possible to detect how long Tramadol stays in your system because it depends on the half-life of Tramadol and the sensitivity of the drug test. Millions of people used Tramadol in the treatment of their health conditions, like moderate to severe pain or chronic pain that does not respond to treatment with another painkiller. The truth is that many factors determine how long Tramadol stays in your system after you take it. In this article, we’ll get a complete idea of how Tramadol works and its effects on the body. Working Mechanism Of Tramadol:- Tramadol effects as a centrally-acting analgesic that works through various mechanisms. It works in the way that the drug causes pain relief through adrenergic and serotonergic activity, while the active metabolite O-desmethyltramadol acts on mu opioid receptors. When we explain the mechanism of action of Tramadol, it is an important factor that its use in the treatment of pain, and how the drug may lead to opioid addiction. How Does Tramadol Work? Similarly, other opioid medications such as Oxycodone, Tramadol work by binding to the brain’s opioid receptors to block pain. It contains monoamine reuptake inhibitors that make Tramadol unique, and these inhibitors help to suppress the depressant effects of opioids. Tramadol can also induce euphoria by triggering the brain to release endorphins and start to work within an hour after taking it. Immediate-release Tramadol is effective for up to 6 hours, whereas Extended-release Tramadol works for about 12-24 hours. How Long Does Tramadol Stay In Your Body? The drug Tramadol can be detected in various drug tests, including saliva, urine, blood, and hair. It’s also possible that you will test positive for it for different periods depending on the test. Below, you will find the timeframes for how long Tramadol can be detected by different drug tests. Tramadol in Saliva: Saliva test involves taking an oral swab and sending it to the lab for testing the presence of Tramadol, and it has a short detection window. These tests can help to detect Tramadol for up to 2 days after the last dose. Urine Test For Tramadol: If you have to take a urine for know how long Tramadol stays in your system, the answer is that it can be detected for up to 4 days after the last dose. But an extended-release Tramadol can be detected in urine for longer. Tramadol In Blood: Blood tests are rarely conducted to detect Tramadol because it doesn’t stay in the blood. Normally, a blood test can come out positive within 24 hours, but if you are using extended-release, this test can remain positive for a longer time. Tramadol In Hair: To detect Tramadol in the system, a hair test is highly accurate and has the longest detection window, also needed to determine chronic drug use, These tests can detect Tramadol for up to 90 days after the last use. Tramadol Half-Life: It is well detected through the half-life of Tramadol how long Tramadol stays in your system. Tramadol can stay in a person’s system for nearly two days, so this drug has a half-life of 6.3 hours, but multiple doses are estimated to be 7 hours. Factors Responsible For How Long Tramadol Stays In Your System Different factors may affect how long Tramadol stays in your system. So, when using Tramadol, be careful and keep these facts in your brain: Age: Blood concentration increases with age. So, younger individuals may metabolize drugs faster than older individuals. Hence, the younger can eliminate Tramadol faster. Gender: There are biological differences between males and females, and kidney or liver functions are also different. Tramadol concentration in women is about 12% higher than in men. So, it tends to stay longer in a woman’s body than a man’s. Metabolism: Drug metabolism refers to the changing it to a simpler form. People who have a slower metabolic rate will take longer to break down the drug. Other Medication: Taking multiple medications together may affect the elimination process. Liver & Kidney Function: Drugs are processed by the liver and kidneys. So, if you have poor kidney or liver function, it may take your body longer to eliminate Tramadol from your system. What Are The Signs of Tramadol Addiction? For those who use Tramadol, it is important to remember that before taking this medication, visit a healthcare provider and, after their guidance, use it properly. If you have become dependent on the drug, it will cause withdrawal symptoms, which are difficult to manage. Treatment centres offer proper guidance and support to help you ease withdrawal symptoms. Many symptoms indicate Tramadol addiction, such as low blood pressure, seizures, decreased heartbeat, slow breathing, and intense drowsiness. What Are The Tramadol Withdrawal Symptoms People who take opioids as prescribed by a doctor for short-term pain relief rarely face withdrawal. And chronic pain patients who take the drugs as prescribed may become addicted and experience withdrawal symptoms. Some withdrawal symptoms include: Sweating Muscle aches Headache Diarrhea Insomnia Fatigue Depressed Mood changes