Opana ER 30 Mg is a tricyclic antidepressant with sedative effects. Opana ER 30 Mg affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood. Opana ER 30 Mg is a prescription medicine used to treat symptoms of depression. Opana ER 30 mg comes in a Red Colored, Octagonal(Eight Sided) Pill Shape. One side of the tablet has "30" written on it,