Oxycodone is used to treat moderate to severe pain. Oxycodone 80 mg is the largest dose of Oxycodone. The smallest dose is Oxycodone 5 mg. It is used to treat cancer pain or pain from surgery in patients. Do not decide the dose on your own. Use this medicine in the exact way you are directed by your doctor. Interaction of this medicine with some other medicines can lead to some serious issues.