Buy Oxycodone Mayomeds is a powerful opioid used to manage moderate to severe pain. Because of its potency and potential for abuse, it's classified as a controlled substance in many countries, including the United States. This means it should only be used under the direct supervision of a licensed healthcare provider. It is used for both short-term and long-term pain, but should only be used under a doctor’s care. Doctors give oxycodone to people who have: Pain after surgery, Injury pain like broken bones, Cancer pain, and Long-term pain that doesn’t go away with other medicines.