Premature ejaculation (PE) is one of the most common forms of sexual dysfunction occurring in males at any given stage of their life. It has been researched and studied that premature ejaculation also has a significant impact on the duration and quality of sexual intercourse, thereby resulting in anxiety and depression, and even affecting relationships between partners. A sexual disorder such as premature ejaculation in men is increasingly becoming recognised for the psychological problems, somatic disorders, and/or neurobiological disturbances, and polymorphisms of the serotonin (a type of neurotransmitter used in sleep, depression, and memory) transporter or its promoters that frequently co-occur in the same individual.