For best results, take the hangover relief tablets right after your last drink or before going to bed. These after-party tablets work most effectively when consumed early, helping your body detox, rehydrate, and restore lost nutrients overnight. If you miss taking them before sleep, you can still take these hangover cure tablets or hangover headache tablets the next morning to reduce nausea, headache, and fatigue. These night-out tablets act as a quick hangover relief pill and are ideal as an after-party medicine to feel fresh and active. Conclusion: To maximize the effect of your hangover cure pill, take it at night before sleep or early the next morning. Quick action ensures faster recovery and a headache-free morning.