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Popular ED Medications in This Category • Sildenafil • Tadalafil • Vardenafil • Avanafil How Do ED Medications Work? ED medications work by increasing blood flow to the penis, helping men achieve and maintain erections when sexually aroused. Most belong to the PDE5 inhibitor class, which enhances the natural response to sexual stimulation. Mechanism of Action: • Sexual arousal releases nitric oxide (NO) in the penile tissues. • This increases levels of cyclic guanosine monophosphate (cGMP), relaxing smooth muscle and allowing blood to flow into the penis. • PDE5 enzymes break down cGMP, weakening the erection. • ED drugs block PDE5, maintaining cGMP levels and supporting a stronger, longer-lasting erection. 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