Combining Xanax and Adderall can be dangerous due to their opposing effects—Xanax is a sedative, while Adderall is a stimulant. This mix can strain the heart and nervous system. It may also mask each drug’s effects, increasing the risk of overdose. Always consult a doctor before mixing medications.Long-term use of both can lead to dependence, withdrawal symptoms, and mental health complications. Misuse significantly raises the risk of addiction and life-threatening side effects.