Vicodin is the most popular medication for use to decrease severe pain. It is necessary before taking this medicine you should consult your doctor. Read all the possible points of the leaflet or the medication guide. Always connect with your doctor if you are confused about the dosage and food to take. According to the doctor, you should take the exact dose. Take the tablet by mouth with food or without food. You can take doses between the 4-6 hour gap if pain again irritates you. Inform your doctor if you are taking Valium, Ativan, alprazolam, lorazepam, Xanax, Klonopin, or sleeping pills like Halcion and Sonata, or any other medicine.