Lortab 5-325 mg is a combination medicine of two drugs named Acetaminophen and Hydrocodone. Lortab is an opioid medication used as a pain reliever for moderate pain. It has two other doses namely Lortab 7.5-325 mg and Lortab 10-325 mg. Lortab is an addictive drug. This is a narcotic medicine, misuse, and overdose of this can lead to death. Seek immediate medical attention if you find any allergic reaction after taking it. Use the exact way it is prescribed to you. Tell your doctor about your other health conditions or if you are taking any other medicines or if you are a pregnant or breastfeeding mother.