Oxycodone and Ibuprofen are both used to manage pain, but they work differently. Oxycodone is a strong opioid prescribed for moderate to severe pain, while Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for mild to moderate pain and inflammation. Choosing between them depends on pain severity, medical history, and risk of side effects. Always consult a healthcare professional before combining or switching pain medications.