Adderall and Wellbutrin are prescription medications that affect the brain’s neurotransmitters but serve different purposes. Adderall is a stimulant used to treat ADHD and narcolepsy, while Wellbutrin is an antidepressant used for depression and to support smoking cessation. When taken together, they may enhance focus, energy, and mood, but combining them should only be done under medical supervision due to potential interactions and side effects.