Oxycodone and Percocet are both prescription pain medications, but they are not the same. Oxycodone is a single active opioid used for moderate to severe pain, available in immediate- and extended-release forms. Percocet, on the other hand, combines oxycodone with acetaminophen, enhancing pain relief but also increasing the risk of liver damage if overused. Comparing oxycodone vs Percocet helps patients understand how each works, their potential side effects, and when one may be preferred over the other.