Polyclonal and monoclonal antibodies play vital roles in research, diagnostics, and therapies, but they differ in origin and application. Polyclonal antibodies are produced by multiple immune cell lines, recognizing various epitopes of an antigen, offering broader detection. Monoclonal antibodies come from a single clone, targeting one specific epitope, ensuring higher precision and consistency. Comparing polyclonal vs monoclonal antibodies helps in selecting the right tool for laboratory use, medical diagnostics, or treatment development.