OxyContin and morphine are strong opioid medications used to manage moderate to severe pain, but they differ in formulation and usage. OxyContin is the extended-release form of oxycodone, providing long-lasting relief for chronic pain. Morphine, one of the oldest opioids, is available in immediate- and extended-release forms and is often used in hospital and palliative care settings. Comparing OxyContin vs morphine helps patients and caregivers understand their effectiveness, side effects, and appropriate medical uses.