Yes, workplace stress, especially when chronic and unmanaged, can contribute to the development of clinical depression. While occasional stress is normal and even motivating, persistent exposure to excessive demands, lack of control, toxic work culture, or poor work-life balance can overwhelm a person’s coping mechanisms. Stress affects brain chemistry by elevating cortisol, the stress hormone, which over time can interfere with mood regulation and sleep cycles. This can lead to symptoms such as irritability, fatigue, feelings of hopelessness, and loss of interest in work and daily life — hallmarks of depression. Additionally, lack of social support at work, job insecurity, or bullying may intensify the emotional strain. If unaddressed, the stress-depression cycle worsens, impairing productivity, increasing absenteeism, and sometimes resulting in burnout. Employers can help by creating supportive environments, offering flexible schedules, and providing mental health resources. Individuals can benefit from therapy, mindfulness, regular exercise, and setting boundaries. If workplace stress feels overwhelming, professional help can prevent escalation into depression.