Millions of people in the USA are affected by pain in numerous ways. They need a perfect solution to manage their moderate to serious pain. In that, everyone knows about two widely used opioids OxyContin and Hydrocodone, that acts as the first line of treatment for managing extreme pain. Both drugs are powerful pain relievers because of their pain-alleviating qualities, as they help to block the pain signals, thus making the body relaxed instantly. While Hydrocodone and OxyContin are quite similar, they differ greatly in potency, duration, and potential hazards.