Pain management is a unique process for each individual. There are a lot of types of treatments available in pain management, but the two main and commonly prescribed painkillers that work in such different ways are Tramadol and Celecoxib. Celecoxib, an NSAID medication for arthritis-like pain that reduces inflammation. On the other hand, Tramadol, an opioid for pain that is prescribed for moderate to severe pain. Both are recommended for pain treatment, but they differ in mechanism of action, side effects, and uses.