Tramadol vs Percocet: Which opioids are best used to treat pain? Percocet contains oxycodone and is more potent than tramadol, so it requires a smaller dose to produce effects. Both Tramadol and Percocet are addictive and habit-forming. When taken illegally, it can produce both a sedated and euphoric high. Both drugs can cause addiction. Doctors do not prescribe either for long-term use.