Oxycodone and Gabapentin are two prescription medications sometimes used together to manage moderate to severe pain, particularly when nerve pain (neuropathic pain) is involved. Oxycodone is a potent opioid analgesic that targets pain signals in the brain, while Gabapentin is an anticonvulsant that calms overactive nerve activity responsible for chronic pain sensations. When combined under medical supervision, these medications can provide enhanced pain control for conditions such as post-surgical pain, nerve damage, or fibromyalgia.