People often ask, “Is Hydroxyzine the same as Benadryl?” The answer is no while both belong to the antihistamine class, they are different medications with unique uses and effects. Hydroxyzine (found in brands like Atarax and Vistaril) is a prescription-only medication used to treat allergies, anxiety, nausea, and insomnia. It also has calming and sedative properties, making it useful before surgeries or for anxiety management. Benadryl, on the other hand, contains diphenhydramine and is available over the counter. It’s commonly used for seasonal allergies, itching, cold symptoms, and short-term sleep aid.