When comparing Oxycodone vs Percocet, it’s important to know that while they are closely related, they’re not the same medication. Oxycodone is a powerful opioid pain reliever used alone to treat moderate to severe pain. It directly targets the brain’s pain receptors, providing effective relief for chronic or post-surgical pain. Percocet, on the other hand, combines Oxycodone with Acetaminophen (Tylenol), enhancing pain control but also increasing the risk of liver damage if taken in high doses.