Hydrocodone 10-500mg is primarily used for to treat severe chronic pain that requires opioid analgesia and is not effectively treated by nonopioid alternatives. Hydrocodone is used in combination formulations to treat nonproductive cough in adults and has antitussive properties.An opioid pain reliever used to treat moderate to severe pain. It works by side effects the brain and central nervous system to reduce the perception of pain. A non-opioid analgesic that helps relieve pain and reduce fever. It enhances the pain-relieving effects of hydrocodone.It takes about 20 minutes to start working. This often happens with the 1st dose or if you change doses. Tell your care team about any other side effects. Drinking 6 to 8 glasses of water a day can help prevent constipation.you should know that hydrocodone may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. you should know that hydrocodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position.dizziness, lightheadedness, and fainting when you get up too quickly from a lying position.