CLICK HERE TO BUY HYDROCODOME M365 Hydrocodone M365 is a commonly prescribed prescription medication used for the management of moderate to moderately severe pain. The marking “M365” identifies a white, capsule-shaped tablet that contains a combination of two active ingredients: hydrocodone bitartrate (5 mg) and acetaminophen (325 mg). Hydrocodone is an opioid pain reliever that works by altering how the brain and nervous system perceive pain, while acetaminophen enhances pain relief and helps reduce fever.