Safety and Interactions of Aspirin and Oxycodon While it is generally safe to take oxycodone and aspirin together under a doctor’s guidance, combining these medications should always be done with caution and professional medical oversight. Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug (NSAID) and a common over-the-counter pain reliever, fever reducer, and anti-platelet agent. […]