The article explains the role of the mitochondrial-derived peptide MOTS-c as a regulator of cellular metabolism, inflammation, and immune responses. It describes how MOTS-c functions within the body’s mitokine network to support metabolic homeostasis, enhance insulin sensitivity, and activate cellular energy pathways. The piece emphasizes MOTS-c’s anti-inflammatory effects, including reducing pro-inflammatory cytokines (such as IL-6, IL-1β, and TNF-α) and increasing anti-inflammatory cytokine IL-10, as well as its ability to improve immune function by enhancing macrophage bactericidal activity and tolerance to infection. It also discusses the decline of MOTS-c levels with age, the peptide’s potential in addressing age-related inflammation, and its broader implications for healthy aging and immune regulation.