Norco 7.5-325 mg is a prescription pain medication used to manage moderate to moderately severe pain. The numbers describe the strength of its two active ingredients: Hydrocodone 7.5 mg – an opioid analgesic that alters how the brain perceives pain. Acetaminophen 325 mg – a non-opioid pain reliever that also helps reduce fever and enhances pain control. This strength is often prescribed when lower doses are not effective, but a higher dose is not yet needed, such as after surgery, dental procedures, or injury. Norco usually starts working within 30–60 minutes.