???? CLICK TO ORDER – Exclusive 30% OFF! ???? Vicodin 5-500 mg is a prescription medication commonly used for short-term relief of moderate to severe pain. It combines hydrocodone, an opioid analgesic, with acetaminophen to help manage pain when other treatments are not sufficient. Because Vicodin affects the central nervous system and carries a risk of dependence, it is tightly regulated and must be used under medical supervision