Moderate to moderately severe pain is treated with a prescription medication called Norco 5-325 mg. Its two active ingredients are hydrocodone bitartrate (5 mg) and acetaminophen (325 mg). While hydrocodone is an opioid analgesic that works by changing how the brain and nervous system respond to pain, acetaminophen is a non-opioid pain reliever and fever reducer that enhances overall pain control.