Vicodin is a prescription pain medication that combines hydrocodone, an opioid analgesic, with acetaminophen to help manage moderate to severe pain. It is commonly prescribed for post-surgical recovery, injury-related pain, and certain chronic pain conditions when other treatments are insufficient. How Vicodin Works The hydrocodone component works by reducing pain signals in the brain, while acetaminophen enhances pain relief and helps reduce fever. Together, they provide effective pain control that can support daily functioning during recovery periods.