Don’t Miss Out! Get Up to 50% Off Your Order Now! ???? What Is Vicodin (Hydrocodone/Acetaminophen)? Vicodin is a combination pain medication containing: Hydrocodone — an opioid pain reliever Acetaminophen — a non-opioid analgesic It’s typically prescribed for moderate to severe acute pain, such as after surgery, injury, or certain medical conditions. This medication is powerful but potentially risky — misuse can lead to respiratory depression, dependence, overdose, and liver damage (due to acetaminophen). That’s why it’s regulated and not available freely online.