A prescription medication called Norco 5-325 mg is used to treat moderate to moderately severe pain. Its two active ingredients are hydrocodone bitartrate (5 mg) and acetaminophen (325 mg). Acetaminophen is a non-opioid medication that reduces temperature and relieves pain in general. Hydrocodone, on the other hand, is an opioid analgesic that works by changing the way the nerve system and brain respond to pain.