When conventional painkillers are ineffective, a prescription drug called Norco 10-325 mg is used to treat moderate to severe pain. It contains 325 mg of acetaminophen and 10 mg of hydrocodone bitartrate. While acetaminophen is a non-opioid analgesic that helps lower pain and fever and intensifies the overall pain-relieving impact, hydrocodone is an opioid pain reliever that acts by altering pain signals in the brain and nervous system.