If you have ever had to take more than the average pain medication, then you have probably heard of both of these. The question of Tramadol vs Hydrocodone which is stronger, is often a common question, but it’s not that simple. What may work for one person may not work for another. When comparing Tramadol vs Hydrocodone in terms of strength, the biggest difference between the two is how strong and how fast they work. Tramadol is usually for people who have moderate pain. It takes a while to work by affecting how your brain perceives pain, giving you steady relief. Hydrocodone is stronger and faster-acting, but it also has a higher chance of side effects and addiction. Just because one is stronger doesn’t mean it’s better. It all depends on what kind of pain you have and how your body reacts to it.