Post-operative pain and similar forms of severe pain pose a serious issue which can only be managed by powerful painkillers. These chronic pains are dealt with opioid painkillers. Two common opioids that can deal with both moderate pain and discomfort that need medical supervision are Fentanyl and Tramadol. Tramadol is one of the most effective pain relievers used for the last three decades. Fentanyl is one of the strongest pain relievers available today in hospital settings. One of the major disadvantages of using the two opioids is their high potential for addiction. Let us compare Fentanyl vs Tramadol to understand which drug can cause more harm to our health if misused.