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Immediate-release forms of the drug are available in oral tablet form; extended-release forms of the drug are available as capsules to be taken by mouth.1,2 The effects of Adderall last for varying amounts of time depending on the version of the drug. The immediate-release Adderall version will last around 4­–6 hours per dose, while Adderall XR, the extended-release version, only needs to be taken once each morning How Long Does Adderall Last? Adderall is absorbed in the gastrointestinal tract and either deactivated by the liver or eliminated unchanged in the urine. About 20-25% of it is converted to metabolites, including hippuric and benzoic acids.5 The rate at which the drug is eliminated can be affected by the pH of the person’s urine. How long Adderall stays in a person’s system depends on a number of factors. For example, the rate at which the drug is eliminated from a person’s body can be affected by the pH of the person’s urine. A person with a low urine pH will tend to eliminate the drug faster, while a person with a higher pH may eliminate the drug more slowly.5 Other factors that can affect how long Adderall stays in a person’s system include:6 How often the person took Adderall. What dose the person took. When the person last took Adderall. Weight. Kidney or liver impairment. Employers, law enforcement, medical and mental health professionals, and sports organizations commonly test for amphetamines. Urine tests, blood tests, hair tests, and saliva tests are all used to determine whether a person has used Adderall or similar drugs. Urine test: This is the most commonly used form of testing. You are most likely to test positive for Adderall on a urine test 72-96 hours after last use. Hair test: Though less commonly used than urine tests, hair tests offer a greater window of possible detection time. Traces of amphetamines can be detected for up to 3 months after last use.8 Saliva test: Traces of Adderall can be detected in saliva for 20-50 hours.7 Blood test: While traces of Adderall can be detected soon after last use, it will only remain in the blood for up to 46 hours. Is Adderall Addictive? As stated earlier, Adderall abuse can lead to addiction. An addiction can interfere with many areas of a person’s life, such as their health, relationships, schoolwork, or employment.4 Signs of addiction include:4.9 Taking Adderall in larger amounts or over a longer period of time than intended. Inability to cut back on Adderall use. Spending a large amount of time acquiring Adderall, using it, or recovering from its effects. Craving Adderall. Difficulty taking care of responsibilities at work, school, or home due to Adderall use. Continuing to use Adderall even though its use is causing social or interpersonal problems. Not participating in previously enjoyed activities in favor of Adderall use. Using Adderall in dangerous situations. Continuing to use Adderall even though it is causing physical or psychological problems. Building tolerance to Adderall, so that the person has to take progressively higher doses of the drug to get the same effect as before. Withdrawal symptoms when the person cuts down or stops use. Abuse and addiction also increase the risk of overdose. People who develop tolerance to the drug may steadily increase their intake of Adderall, raising the likelihood of taking too much and overdosing. Symptoms of an Adderall overdose include:1 Panic. Confusion. Hallucinations. Aggression. Nausea. Vomiting. Abdominal cramps. Diarrhea. Rapid breathing. High fever. Rhabdomyolysis (breakdown in muscle tissue that releases a damaging protein into the blood, which can damage the kidneys). Irregular heartbeat. High or low blood pressure. Circulatory collapse. Restlessness. Tremors. Overactive reflexes. Convulsions. 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