Oxycodone 80 mg is a high-dose, prescription-only opioid used for managing severe chronic pain, typically under close supervision from a licensed medical professional. It has a high risk of addiction, misuse, and overdose, especially when not taken as prescribed. Oxycodone 80 mg strength of oxycodone is typically reserved for patients who are opioid-tolerant—meaning they have been using opioid therapy for a prolonged period and require a higher dose to manage their pain effectively. It is not recommended for individuals who are opioid-naïve, due to the risk of life-threatening respiratory depression and overdose.