Ketamine and Cocaine differ in class and effects. Ketamine is a dissociative anesthetic that can cause detachment from reality, used medically for anesthesia and depression treatment. Cocaine is a powerful stimulant that increases energy, alertness, and euphoria. Ketamine slows brain activity, while cocaine accelerates it. Both can be misused and cause serious risks, but cocaine has higher cardiovascular danger, while ketamine can impair perception and cognition.