Drinking alcohol while taking it can be fatal. This can have some very serious side effects. Consult your doctor instantly if you get any life-risking issues. You should not take this medicine if you are allergic to Oxycodone. It can be very harmful to take this medicine with other opioid or narcotic medicines. Some medicines like Xanax, clonazepam or Klonopin, diazepam or Valium, lorazepam.