Tweaking refers to a state of intense restlessness, anxiety, or agitation that often happens after prolonged drug use, especially stimulants. People who are tweaking may have trouble sleeping, appear paranoid, act impulsively, or show unusual movements and behavior. This condition is usually caused by chemical changes in the brain due to substance use and lack of rest or nutrition. Tweaking can be risky, as it may lead to accidents, health problems, or unsafe decisions, making early support and treatment important.