Xanax and Zoloft are prescription based medicine that are used to reduce anxiety. Both medicines work differently. Xanax works fast and quickly by calming the brain. Short-term use of xanax can be helpful, but misuse or long-term use of xanax can cause serious side effects, such as Drowsiness, tiredness, and dizziness, Sleep problems (insomnia), and memory problems. Poor balance or coordination. Slurred speech. Trouble concentrating. Zoloft works slowly by controlling the brain. It takes a week to fully recover. Doctor are suggested zoloft for long-term treatment. Choosing better for anxiety totally depends on individuals. If they want quick pain relief, then use xanax and slow and long-term use of Zoloft.