Worldwide, severe pain during surgeries and some painful operations is managed by some powerful opioids, but the most commonly used highly potent synthetic opioid is fentanyl, which is famous for its potential of being misused. And it is more deadly if it is mixed by other drugs. Now, everybody knows what kind of effects Fentanyl has on your brain and your respiratory organs. In some cases, heart attacks due to Fentanyl can also occur. But many people are now questioning its effects on other organs, too. The most common one is “Does Fentanyl affect kidney function?” and what are the Fentanyl effects on the kidneys? In this article, we are going to answer these questions.